Yup, to take most advantage of titanium, parts made from it must be designed with its properties in mind from beginning. Due to its lower strength, parts must be oversized relative to their steel countreparts. The Litespeed frame has larger diameter and thicker tubing than chromoly frame.
Same thing with moto parts like axles and handlebars. Unfortunately in this case, not being able to increase diameter of axle meant increasing wall thickness over steel part and negating lots of potential weight savings.