Yup, to take most advantage of titanium, parts made from it must be designed with its properties in mind from beginning. Due to its lower strength, parts must be oversized relative to their steel countreparts. The Litespeed frame has larger diameter and thicker tubing than chromoly frame.For me, besides safety, another thing to consider is liability. If I went with titanium axles and had a failure, if I were lucky enough to survive, I would almost certainly not be covered for the damage to my motorcycle, much less myself. Just doesn't seem worth it.
I'm a big fan of titanium. I have two Litespeed titanium MTB frames, with titanium handlebars, seatposts, pedal spindles, skewers, fasteners and a 6-4 stem which is now unobtanium. I just don't think it makes sense for liter bike motorcycle axles given the small weight savings versus risk.
Same thing with moto parts like axles and handlebars. Unfortunately in this case, not being able to increase diameter of axle meant increasing wall thickness over steel part and negating lots of potential weight savings.